Carnosine protects human microglia against Aβ oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis
These results demonstrate the protective effects of carnosine on human microglial cells against detrimental alterations induced by Aβ oligomers, underlining the multimodal mechanism of action of this dipeptide and supporting its promising potential in the context of AD pathology.
Authors
- Andréa Graziani (ORCID: https://orcid.org/0009-0003-2989-4183)
- Lucia Di Pietro (ORCID: https://orcid.org/0000-0002-9314-4788)
- Francesco Bellia (ORCID: https://orcid.org/0000-0002-9273-5949)
- Giuseppe Carota
- Vincenzo Cardaci (ORCID: https://orcid.org/0000-0002-7050-1375)
- Jay Sibbitts (ORCID: https://orcid.org/0000-0002-1007-9918)
- Lucia Bucarello
- Susan M. Lunte
- Matthew Zupan
- Meredith D Hartley
- Renata Mangione
- Emiliano Maiani
- Barbara Tavazzi
- Giuseppe Caruso
- Giuseppe Lazzarino
- Giacomo Lazzarino
- Anna Privitera
- Angela M. Amorini
Institutions
- University of Kansas (US)
- Department of Health and Aged Care (AU)
- University of Catania (IT)
- Oasi Maria SS (IT)
- Bioanalytica (Switzerland) (CH)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Biotech Park (IN)
- IRCCS San Camillo Hospital (IT)
- Fondazione CRT (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fimmu.2026.1768094
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00