Analytical validation of a metagenomic next-generation diagnostic platform for urinary tract infection in a Thai tertiary hospital setting: a BI-Biotia UTI cohort study
The BIOTIA-DX platform demonstrates robust analytical concordance with urine culture in a Thai patient population. Prospective clinical validation studies are needed to assess clinical utility and impact on patient outcomes, particularly in culture-negative and polymicrobial cases. This study represents the first analytical validation of this platform using Oxford Nanopore Technology and the first validation in Southeast Asia.
Authors
- Montinee Sangtian
- David Danko (ORCID: https://orcid.org/0000-0002-1456-9498)
- Sira Sriswasdi (ORCID: https://orcid.org/0000-0002-4117-3632)
- Mara Couto-Rodriguez (ORCID: https://orcid.org/0000-0002-9799-0068)
- Wichai Techasathit
- Heather Wells (ORCID: https://orcid.org/0000-0002-1724-5843)
- Dorottya Nagy‐Szakal
- Niamh B O’Hara
- Gábor Fidler
- Teeradache Viangteeravat (ORCID: https://orcid.org/0000-0002-1337-1762)
- Wipa Panmontha
- Panupong Wangprapa
- Srichan Bunlungsup
- Christopher E. Mason
Institutions
- Chulalongkorn University (TH)
- SUNY Downstate Health Sciences University (US)
- Bumrungrad International Hospital (TH)
- BioScientia (Poland) (PL)
- Skin Wellness Center (US)
- Artificial Intelligence in Medicine (Canada) (CA)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fcimb.2026.1751074
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00