Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers
This study identifies CDCA as a key protective metabolite in DF. Reduced serum CDCA levels are independently associated with increased risk of DF. Functional evidence confirms that CDCA mitigates high glucose-induced fibroblast dysfunction and promotes wound repair processes. Targeting the CDCA signaling pathway or supplementing CDCA may represent a novel therapeutic strategy for DF by remodeling the "metabolic microenvironment".
Authors
- Keyan Hu (ORCID: https://orcid.org/0000-0001-5671-5660)
- Huifang Peng
- Yujin Ma
- Hetao Chen (ORCID: https://orcid.org/0009-0004-0883-6993)
- Lulu Chen (ORCID: https://orcid.org/0000-0003-0167-4632)
- Ran Guo (ORCID: https://orcid.org/0000-0003-1593-989X)
- Tao Jiang (ORCID: https://orcid.org/0009-0002-6220-9929)
- Lu Lv
- Ying Li
- Jiangying Chang
- Ran Chen
Institutions
- Hubei University of Medicine (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- Xiang Yang No.1 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fendo.2026.1754743
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Henan University of Science and Technology
- Henan University