Designing Skin-Interactive Nanoformulations in Cosmetics: A Structure–Delivery–Dermatological Impact Framework for Next-Generation Cosmeceuticals

The application of nanotechnology in cosmetic science has led to the development of advanced cosmeceutical systems capable of overcoming the limitations of conventional topical formulations. Skin-interactive nanoformulations, including liposomes, nanoemulsions, solid lipid nanoparticles, and nanostructured lipid carriers, enhance the stability, bioavailability, controlled release, and targeted delivery of active cosmetic ingredients. This paper presents a comprehensive Structure–Delivery–Dermatological Impact (SDDI) framework linking nanocarrier physicochemical design to skin penetration pathways and dermatological outcomes. Dermatological applications in anti-aging, photoprotection, pigmentation control, acne management, and barrier repair are critically discussed, along with safety and regulatory considerations.