Manganese modulates hepatocellular carcinoma cytotoxicity and doxorubicin sensitivity in a dose dependent manner
This research elucidates the impact of Mn²<sup>+</sup> concentration on HCC cell behavior, offering a theoretical basis for Mn²<sup>+</sup>'s potential use in HCC treatment. The findings contribute to a deeper understanding of Mn²<sup>+</sup>'s role in HCC and may inform future therapeutic strategies.
Authors
- Zi-yun He
- Hao-lun Wang
- Ting Tang (ORCID: https://orcid.org/0000-0002-5952-4023)
- Yu-An Xie
- Qian-qing Fan
- Zhi-hui Liu
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fonc.2026.1715702
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00