Exploring Causal Associations Between Plasma Metabolites and Sciatica: A Two-Sample Mendelian Randomization Analysis
This study provides genetic evidence supporting a causal role of specific plasma metabolites in sciatica risk, highlighting the involvement of bilirubin and amino acid/sphingolipid metabolism in its pathogenesis. These findings offer novel insights into the biology of sciatica and may inform future research into therapeutic strategies.
Authors
- Yi Luo (ORCID: https://orcid.org/0000-0003-1479-6081)
- Gang Wu (ORCID: https://orcid.org/0000-0001-8711-9124)
- Shaoyong Yu
- Qiuyu Wei
Institutions
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jpr.s568746
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangxi University