Immediate Postoperative Evolution of Cerebral Doppler and Saturation Parameters After Cardiopulmonary Bypass in Infants With Congenital Heart Disease: A Prospective Cohort Study
In neonates and infants following CPB, MCA velocities reach its lowest point approximately 9 hours post-CPB, coinciding with the highest AVo2 difference and previously published nadir of cardiac output. These findings could suggest a period of relative cerebral hypoperfusion. Future studies should evaluate whether targeted interventions guided by multimodal cerebral monitoring can mitigate the risk of acute and long-term brain injury in this vulnerable population.
Authors
- Pierre-Luc Bernier
- Samara Zavalkoff (ORCID: https://orcid.org/0000-0002-4447-1977)
- Marina Mir (ORCID: https://orcid.org/0000-0003-4677-7520)
- Nicole O’Brien
- Ana Roche Martínez (ORCID: https://orcid.org/0000-0001-8295-1982)
- Adrian Dancea
- Gabriel Altit (ORCID: https://orcid.org/0000-0001-5141-0964)
- Kerri L. LaRovere (ORCID: https://orcid.org/0000-0002-0901-4279)
- Guillaume Maître (ORCID: https://orcid.org/0000-0002-8859-1399)
- P. Fontela
- Sam D. Shemie
Institutions
- Universitat Autònoma de Barcelona (ES)
- Nationwide Children's Hospital (US)
- Harvard University (US)
- Montreal Children's Hospital (CA)
- McGill University Health Centre (CA)
- McMaster Children's Hospital (CA)
- Mother Hospital (IN)
- Institute of Research and Innovation Parc Tauli (ES)
- McGill University (CA)
- University of Lausanne (CH)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1097/cce.0000000000001364
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00