Prognostic Significance of Isolated Tumor Cells and the Role of Immunohistochemistry in Nodal Evaluation in Breast Cancer: A SEER-Based Analysis and Reappraisal

ITCs are associated with worse BCSS and OS despite classification as node-negative. Omitting IHC may obscure their detection. Incorporating IHC into routine nodal evaluation may enhance prognostic assessment and guide treatment decisions.

Authors

Seyed Reza Taha
Fouad Boulos

Institutions

Washington University in St. Louis (US)

Publication Details

Journal: JCO Precision Oncology
Published: 2026-02-01
DOI: https://doi.org/10.1200/po-25-00974
Primary Topic: Breast Cancer Treatment Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Prognostic Significance of Isolated Tumor Cells and the Role of Immunohistochemistry in Nodal Evaluation in Breast Cancer: A SEER-Based Analysis and Reappraisal

Seyed Reza Taha, Fouad Boulos

Feb 1, 2026

JCO Precision Oncology

Breast Cancer Treatment Studies

article

Prognostic Significance of Isolated Tumor Cells and the Role of Immunohistochemistry in Nodal Evaluation in Breast Cancer: A SEER-Based Analysis and Reappraisal

Seyed Reza Taha, Fouad Boulos

February 1, 2026article en

Abstract

JCO Precision OncologyVol. 10(2)

Washington University in St. Louis (US)

Good health and well-being

Openalex Percentile: Top 59%

Breast Cancer Treatment Studies

DOI Source OpenAlex

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