Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease
Baseline cholinergic system changes associate with varying cognitive trajectories in mild-moderate PD. Assessment of regional cholinergic deficits may be useful for prediction of cognitive trajectories in this population, enhancing subject selection and stratification for intervention trials aimed at improving cognition in PD.
Authors
- Jaimie Barr
- Prabesh Kanel (ORCID: https://orcid.org/0000-0003-1418-2960)
- Stiven Roytman (ORCID: https://orcid.org/0000-0001-8823-3287)
- Taylor Brown (ORCID: https://orcid.org/0009-0004-6421-1007)
- Giulia Carli
- Roger Albin
- Nicolaas I. Bohnen
Institutions
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- Michigan Medicine (US)
- Parkinson's Foundation (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1002/acn3.70335
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Parkinson's Foundation