Assessing reference ranges for non-HLA antibodies: Comparative analysis of blood donors and kidney transplant candidates

This study demonstrates substantial heterogeneity in non-HLA antibody reactivity across antigens, with consistently lower antibody detection in the WL group. These findings support the concept that immune modulation in transplant candidates may reduce detectable non-HLA antibody levels and provide a rationale for defining reference cut-off values, particularly at the 95th percentile, for this population.