18F-DOPA PET Silence in High-grade Glioma Subtype F
The 2021 WHO classification distinguishes adult-type diffuse gliomas as astrocytoma, oligodendroglioma, and glioblastoma. Recently, a new epigenetic subtype-high-grade glioma IDH-wildtype, subtype F (HGG-F)-has been described, characterized by gliomatosis-like infiltration, low proliferative index, and unexpectedly prolonged survival despite a grade 4 methylation profile. We report the first HGG-F evaluated with 18F-DOPA PET. Despite extensive FLAIR-hyperintense lesions, tracer distribution was entirely normal. This "amino acid PET silence," contrasting with the typically intense uptake in high-grade gliomas, together with the gliomatosis-like MRI appearance, should raise suspicion for this emerging subtype.
Authors
- Lucia Nichelli (ORCID: https://orcid.org/0009-0006-0934-5365)
- Alberto Pïcca (ORCID: https://orcid.org/0000-0001-7807-5393)
- Laura Rozenblum
- Franck Bielle
- Aurélie Kas
- Chloé Quéré
- Bertrand Mathon
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Laboratoire d’Imagerie Biomédicale (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut du Cerveau (FR)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1097/rlu.0000000000006358
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00