Neuropeptide Y regulation of dental pulp neurogenic inflammation provoked by tooth bleaching agents: a descriptive comparative clinical study
The increase in NPY expression-particularly with Opalescence Boost-indicates that in-office bleaching agents can elicit measurable neurobiological responses in pulp tissue after a single application. The significant difference between the control and Opalescence Boost groups suggests a possible H2O2 concentration- or formulation-dependent effect on pulpal neuropeptide activity, underscoring the need for further research on the biological impact of bleaching treatments.
Authors
- Hernan Dario Muñoz‐Alvear (ORCID: https://orcid.org/0000-0002-4327-4242)
- Néstor Ríos-Osorio (ORCID: https://orcid.org/0000-0002-6675-6789)
- Mario Pérez-Villota
- Karolina Aucú-Miño
- Diana Escobar-Mafla
- Edgar Güiza – Cristancho
- Jose Francisco Gomez-Sosa
- Hugo Roberto Munoz
- Luis Diaz-Barrera
Institutions
- Universidad de San Carlos de Guatemala (GT)
- Universidad de La Sabana (CO)
- Instituto Venezolano de Investigaciones Científicas (VE)
- Pontificia Universidad Javeriana (CO)
- Clínica CES (CO)
- Universidad Cooperativa de Colombia (CO)
- Institución Universitaria Visión de las Américas (CO)
Publication Details
- Journal
- Restorative Dentistry & Endodontics
- Published
- 2026-02-13
- DOI
- https://doi.org/10.5395/rde.2026.51.e10
- Primary Topic
- Dental Erosion and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00