Performance of the 2024 McDonald Criteria in Patients Under Evaluation for Suspected Multiple Sclerosis
Use of the 2024 McDonald allows for earlier MS diagnosis, but also more frequent diagnosis including in patients with radiologically isolated syndrome. The revised criteria have similar performance across the lifespan. Limitations include the lack of data on central vein sign and kappa free light chains, and missing optic nerve assessment in some patients.
Authors
- N. A. Losseff
- Wallace Brownlee (ORCID: https://orcid.org/0000-0003-0481-8902)
- Davide Maccarrone (ORCID: https://orcid.org/0000-0002-5873-0191)
- Riccardo Nistri (ORCID: https://orcid.org/0000-0002-5479-8201)
- Dr Yael Hacohen
- Ahmed T. Toosy
- Heather Wilson
- Olga Ciccarelli
- Sarah Wright
- Charmaine Yam
Institutions
- Great Ormond Street Hospital (GB)
- Multiple Sclerosis Society (GB)
- Southern District Health Board (NZ)
- UCL Biomedical Research Centre (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Neurology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1212/wnl.0000000000214688
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 36.00