Protective Effects of Orally Administered Salvia miltiorrhiza–Derived Extracellular Vesicles on Diabetic Kidney Disease: Protection Mediated by Gut Microbiota and Metabolomic Remodeling
SMEVs significantly improve the pathological progression of DKD by reshaping the intestinal flora, restoring metabolic homeostasis and inhibiting inflammatory and fibrotic responses, providing an experimental basis for the application of plant-derived extracellular vesicles in kidney diseases.
Authors
- Jingyi Huang (ORCID: https://orcid.org/0000-0002-1209-9699)
- Liu Li (ORCID: https://orcid.org/0009-0002-1491-2038)
- Jiacheng He (ORCID: https://orcid.org/0000-0002-1940-4262)
- Zhiying FENG
- Rong Yu
- Yi Liu
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/ijn.s580968
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00