Dissecting the causal pathway linking HbA1c to oral cavity cancer via immune cell modulation: a bidirectional mendelian randomization analysis
This study provides genetic and experimental evidence for a protective, immune-mediated role of HbA1c in oral cavity cancer. While AGEs do not directly impact OSCC viability, they impair CD8+ T cell function via oxidative stress, highlighting the interplay between glycemic control, immune modulation, and carcinogenesis.
Authors
- Bo Li (ORCID: https://orcid.org/0000-0002-7294-6888)
- Jieqi Wang (ORCID: https://orcid.org/0009-0006-4565-0906)
- Y. Wang
- Yong Liu (ORCID: https://orcid.org/0000-0001-6697-5052)
- Zhe Zhang
- Meihua Zheng
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- The First People's Hospital of Shunde (CN)
- First People's Hospital of Foshan (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fonc.2026.1768761
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00