7α-acetoxy-6β-hydroxyroyleanone (Roy) modulates IL-6/STAT3/JAK2 mRNA expression and suppresses tumor growth in glioblastoma cell models
These findings, in line with our previous work, underscore the cytotoxic potential of this natural compound, suggesting Roy as a promising lead candidate for future GB treatment strategies.
Authors
- Renato Spigarelli (ORCID: https://orcid.org/0000-0002-1870-7536)
- Eva María Domínguez-Martín (ORCID: https://orcid.org/0000-0002-7884-4292)
- Mariana Magalhães (ORCID: https://orcid.org/0000-0002-1874-1611)
- Enzo Spisni (ORCID: https://orcid.org/0000-0002-8525-2981)
- Célia Cabral
- Thomas Efferth
- Patrícia Rijo
- Lino Ferreira
Institutions
- University of Lisbon (PT)
- Universidad de Alcalá (ES)
- Institute for Biomedicine (IT)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- University of Coimbra (PT)
- Universidade Lusófona (PT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fphar.2026.1728792
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- HORIZON EUROPE Framework Programme
- Fundação para a Ciência e a Tecnologia
- European Social Fund