C–H Arylation of Imidazo[1,2- <i>a</i> ]pyridines and Zolimidines Catalyzed by Synergistic Tripalladium Clusters
Tripalladium cluster <b>[Pd</b><sub><b>3</b></sub><b>]</b><sup><b>+</b></sup><b>-1-3</b> (0.33 mol %) presented superior reactivity in the C-H arylation of imidazo[1,2-<i>a</i>]pyridines and zolimidines with aryl halides compared to palladium monomers and nanoparticles, affording important imidazole[1,2-<i>a</i>]pyridine and zolimidine derivatives that featured excellent fluorescent and pharmaceutical properties. This method highlights the low catalyst usage, mild conditions, scale-up practicality, and broad substrate scope. Mechanistic and kinetic analyses indicated that [Pd<sub>3</sub>]<sup>+</sup> most likely remained intact throughout this synergistic catalytic process.
Authors
- Giovanni Maestri (ORCID: https://orcid.org/0000-0002-0244-8605)
- Didier Astruc (ORCID: https://orcid.org/0000-0002-2258-3126)
- Fen Wu (ORCID: https://orcid.org/0000-0003-4703-5385)
- Yingrui Song
- Yanlan Wang
Institutions
- University of Parma (IT)
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Liaocheng University (CN)
- Institut des Sciences Moléculaires (FR)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c05471
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00