Standardized Extract of Flavonoids from Smilax glabra Alleviates Gouty Arthritis by Multi-Target Inhibition of Neutrophil Extracellular Traps via the Raf/ERK and Histone Citrullination Pathways
SFSG alleviates GA progression by targeting neutrophil-driven inflammation and NETs formation through suppression of Raf/ERK signaling and CitH3 expression, thereby demonstrating its potential as a phytotherapeutic agent for neutrophil-associated pathologies.
Authors
- Daozong Xia (ORCID: https://orcid.org/0000-0002-7902-5002)
- Chenxi Wu
- Wenjing Xu
- Liangxin Chen
- Yihuan Wang (ORCID: https://orcid.org/0000-0001-9222-4949)
- C.‐X. Li
- Fenfen Li
- Yueyue Shi
- Xiaoxi Zhang
- Ziye Xu
- Xinru Xu
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s557809
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00