A nine-gene nicotine-metabolism signature predicts prognosis and characterizes the immune landscape in colon adenocarcinoma
We propose a novel NRG-based prognostic signature that accurately predicts outcomes in COAD. The model highlights the interplay between nicotine metabolism, ECM remodeling, and immune responses, highlighting genes and pathways that may inform future therapeutic stratification.
Authors
- Junyi Zhang (ORCID: https://orcid.org/0000-0002-0001-2971)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-1116-4559)
- Zeng Wang (ORCID: https://orcid.org/0009-0005-4044-5885)
- Danning Wang
- Junliang Li
- Chong Shen
- Jieyi Shen
Institutions
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.21037/jgo-2025-aw-905
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00