Stimulator of Interferon Genes Ablation in T Cells Is Required for the Efficacy of Stimulator of Interferon Genes Agonists in Chimeric Antigen Receptor-T Cell Immunotherapy of Pancreatic Cancer
Our findings suggest that STING knockout CAR-T cells stand to benefit from STING agonists to improve CAR-T cell therapy for immune-deprived cancers such as pancreatic cancer.
Authors
- Ignazio Piseddu (ORCID: https://orcid.org/0000-0001-8331-9778)
- Patrick Layritz
- Lisa Fahr
- Charlotte Marx (ORCID: https://orcid.org/0009-0005-0992-3543)
- David Anz (ORCID: https://orcid.org/0000-0002-4314-777X)
- Ivonne Regel (ORCID: https://orcid.org/0000-0002-0206-4441)
- Daniel Nixdorf (ORCID: https://orcid.org/0000-0003-1612-9952)
- Adrian Gottschlich (ORCID: https://orcid.org/0000-0002-2898-4182)
- Matthias Thaler
- Marleen Bérouti (ORCID: https://orcid.org/0009-0009-6081-5408)
- Andreas Linder (ORCID: https://orcid.org/0000-0002-0623-5105)
- Christine Hörth
- Anne Marie Senz
- Jan Gärtig
- Varvara Varlamova
- Rebekka Endres
- Veit Hornung
- Marion Subklewe
- Catharina Witte
- Sebastian Kobold
- Linda Hammann
- David Illig
- Fabian Lanzl
- Julia Mayerle
- Hannah Fischer
- Alpay Bulut
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- LMU Klinikum (DE)
- German Center for Lung Research (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Gastroenterology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1053/j.gastro.2026.01.031
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00