Mepolizumab for eosinophilic COPD with frequent exacerbations: single-centre real-world experience in a phenotype-directed approach

Mepolizumab significantly reduced exacerbations and hospitalizations in eosinophilic COPD patients with frequent OCS use. A 69% response rate at one year and sustained benefit in the second year support its role in this difficult-to-treat population.

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Publication Details

Journal
Therapeutic Advances in Respiratory Disease
Published
2026-02-01
DOI
https://doi.org/10.1177/17534666251414352
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
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article

Mepolizumab for eosinophilic COPD with frequent exacerbations: single-centre real-world experience in a phenotype-directed approach

Peter A. Kopac, Tina Morgan, Irena Šarc, Igor Požek
Therapeutic Advances in Respiratory Disease
Chronic Obstructive Pulmonary Disease (COPD) Research
article

Mepolizumab for eosinophilic COPD with frequent exacerbations: single-centre real-world experience in a phenotype-directed approach

Peter A. Kopac, Tina Morgan, Irena Šarc, Igor Požek
article en

Abstract

Mepolizumab significantly reduced exacerbations and hospitalizations in eosinophilic COPD patients with frequent OCS use. A 69% response rate at one year and sustained benefit in the second year support its role in this difficult-to-treat population.

Therapeutic Advances in Respiratory DiseaseVol. 20
University of Ljubljana (SI), University Clinic of Pulmonary and Allergic Diseases Golnik (SI)
Reduced inequalities
Openalex Percentile: Top 58%
Chronic Obstructive Pulmonary Disease (COPD) Research
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