Multi-Institutional Study Evaluating the Role of Early Circulating Tumor DNA Dynamics During Treatment With Immune Checkpoint Inhibitors in Patients With Advanced-Stage Melanoma
We found that early ctDNA dynamics after only 3-4 weeks of ICI initiation in patients with advanced-stage melanoma appears to be a candidate strategy to predict overall treatment response, risk of progression, and long-term survival. Larger prospective studies are warranted to validate the utility of early ctDNA changes in treatment monitoring.
Authors
- Joshua M. Lang (ORCID: https://orcid.org/0000-0002-0943-8872)
- T. Vincent
- Adrienne I. Victor (ORCID: https://orcid.org/0000-0001-7130-7366)
- Matthew C. Mannino
- Deepak M. Sahasrabudhe
- Caroline Burkey
- Jennifer L. Schehr (ORCID: https://orcid.org/0000-0003-2123-997X)
- Fauzia Hollnagel
- Alice Zhou
- Alyssa K. Steimle (ORCID: https://orcid.org/0009-0003-1932-0338)
- Amir Forati
- Alexander Birbrair
- Janmesh D. Patel
- Shuang G. Zhao
Institutions
- University of Wisconsin–Madison (US)
- Washington University in St. Louis (US)
- University of Rochester (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1200/po-25-00254
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00