Photoredox-Enabled Radical Ring-Opening Fluorosulfonamidation/Fluorosulfonylmethylation of Methylenecyclobutanols
We report a photoredox strategy for radical-initiated ring-opening fluorosulfonamidation/fluorosulfonylmethylation of methylenecyclobutanols using NFSAP (<i>N</i>-fluorosulfamoylpyridinium salts) and BMSF (bromomethylsulfonyl fluoride) as the respective radical sources. This approach provides efficient access to FSO<sub>2</sub>CH<sub>2</sub>-/FSO<sub>2</sub>N-functionalized γ,δ-unsaturated carbonyl compounds─both FSO<sub>2</sub>CH<sub>2</sub>-/FSO<sub>2</sub>N and γ,δ-unsaturated carbonyl motifs are useful structural scaffolds─while offering good scalability and broad compatibility with postderivatization reactions.
Authors
- Qi Lin (ORCID: https://orcid.org/0000-0001-5026-1100)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Xiaoxing Li
- Ni-Ping Pei
- Li-Jing Wang
- Ye-Pu Fu
- Wei Li
- Lele Zhang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Hebei University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1021/acs.orglett.6c00017
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00