Identifying novel biomarkers for systemic lupus erythematosus associated with macrophage activation syndrome
KLRG1, KLRC3, and ULK2 are potential biomarkers for predicting MAS in SLE patients. Among them, KLRG1 has the highest sensitivity (0.889) and specificity (0.929) for predicting SLE induced MAS, which is considered the optimal biomarker for diagnosing MAS in SLE. These findings position KLRG1 as a minimally invasive, early-warning biomarker that could promptly predict MAS and might guide timely MAS-directed therapy in SLE.
Authors
- Lingjie Cao
- Renge Liang
- Ranran Yao
- Yin Su
- Zhenming Liu
- Fengtao Yang
- Xiao Han
- Xi Wang
- Yuanyuan Pei
- Jihong Zhu
- Yiran Zhou
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
- Case Western Reserve University (US)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1016/j.biopha.2026.119101
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00