Novel Long‐Read Sequencing Method for Characterisation of Hepatitis B Transcripts Show High Expression of Chimeric <scp>HBV</scp> /Human <scp>RNA</scp>
This method enables a simplified and comprehensive analysis of HBV transcripts. The results highlight the predominance of integration-derived RNA and support the presence of cccDNA-independent hepatitis D virus production. Nanopore sequencing offers valuable insights into HBV and HDV biology, supporting its role in understanding viral pathogenesis and therapeutic targeting.
Authors
- Sanna Abrahamsson (ORCID: https://orcid.org/0000-0003-4518-8396)
- Jakob Holm Dalsgaard Thomsen
- Gustaf E. Rydell (ORCID: https://orcid.org/0000-0001-8093-2251)
- Johan Ringlander (ORCID: https://orcid.org/0000-0002-8483-6504)
- Joakim B. Stenbäck (ORCID: https://orcid.org/0009-0004-8831-9100)
- Maria Andersson
- Magnus Lindh
Institutions
- Aalborg University Hospital (DK)
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
- Aalborg University (DK)
Publication Details
- Journal
- Liver International
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1111/liv.70521
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Sahlgrenska Universitetssjukhuset