Integrative omics and experimental validation reveal METTL17 and SLC27A1 as biomarkers and potential therapeutic targets in chronic kidney disease
This study identifies METTL17 and SLC27A1 as key mediators of CKD progression, bridging mitochondrial dysfunction, metabolic reprogramming, and immune imbalance. These findings provide a translational framework for developing biomarker-driven diagnostics and targeted interventions in CKD.
Authors
- Renfa Huang
- Lichang Liang
- Xinyu Shi (ORCID: https://orcid.org/0000-0001-9586-2460)
- Kenan Xie (ORCID: https://orcid.org/0000-0001-9863-0171)
- Penghui Chen (ORCID: https://orcid.org/0000-0001-8252-936X)
- Shiyun Ling
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fimmu.2026.1724740
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00