Transcriptomic and proteomic profiling of pulmonary mucormycosis reveals a failed activation of host immune response
Given the findings of compromised immune function at infection sites, enhancing adjuvant immunotherapy and intensifying localized antifungal treatments may be beneficial for this refractory infection. Our study firstly investigated the immune landscape in pulmonary mucormycosis through combined transcriptomic and proteomic profiling, which could provide novel mechanistic insights for the prevention and treatment of pulmonary mucormycosis.
Authors
- Jinjin Zhong (ORCID: https://orcid.org/0000-0002-9782-9354)
- Yueyan Ni (ORCID: https://orcid.org/0000-0003-0095-0885)
- Die Hu
- Xiaomin Cai (ORCID: https://orcid.org/0009-0002-5878-5579)
- Tingting Zhao (ORCID: https://orcid.org/0000-0002-4466-7785)
- X Su
- Yuchen Cai
- Chao Sun
- Yu Gu
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fimmu.2026.1732782
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project