Inconsistency between serum IgG κ and glomerular IgA λ chain types in proliferative glomerulonephritis with monoclonal deposits successfully treated with daratumumab-based therapy

This rare case of PGNMID showed a discrepancy between serum IgG κ and glomerular IgA λ chain. Treatment with daratumumab, bortezomib, and dexamethasone significantly reduced serum FLC levels and stabilized the blood creatinine level. Daratumumab is a promising drug for the treatment of PGNMID.

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Publication Details

Journal
Medicine
Published
2026-02-13
DOI
https://doi.org/10.1097/md.0000000000044607
Primary Topic
Renal Diseases and Glomerulopathies
Type
article
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article

Inconsistency between serum IgG κ and glomerular IgA λ chain types in proliferative glomerulonephritis with monoclonal deposits successfully treated with daratumumab-based therapy

DUQUN CHEN, Liping Guo, Zhezhe Niu, Yaling Bai et al.
Medicine
Renal Diseases and Glomerulopathies
article

Inconsistency between serum IgG κ and glomerular IgA λ chain types in proliferative glomerulonephritis with monoclonal deposits successfully treated with daratumumab-based therapy

DUQUN CHEN, Liping Guo, Zhezhe Niu, Yaling Bai, Rongfang Zhu, Yi-Xiang Wang, Meijuan Cheng, Guolei Zhang, Zhen Cheng, Huihui Chen, Jingjing Jin, Jinsheng Xu
article en

Abstract

This rare case of PGNMID showed a discrepancy between serum IgG κ and glomerular IgA λ chain. Treatment with daratumumab, bortezomib, and dexamethasone significantly reduced serum FLC levels and stabilized the blood creatinine level. Daratumumab is a promising drug for the treatment of PGNMID.

MedicineVol. 105(7)
Hebei Medical University (CN), Third Hospital of Hebei Medical University (CN), Fourth Hospital of Hebei Medical University (CN), Nanjing University (CN)
Good health and well-being
Openalex Percentile: Top 62%
Renal Diseases and Glomerulopathies
DOIOpen Access PDFOpenAlex
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