Delayed CAVB After SP Ablation for AVNRT: Mechanistic Insights Into FP Injury and Pacing Decision‐Making

As standard therapy for atrioventricular nodal re-entrant tachycardia (AVNRT), radiofrequency ablation of the antegrade slow pathway (SP) is associated with a low risk of AV block. Delayed complete AV block (CAVB), however, is a rare but clinically challenging complication, particularly concerning permanent pacemaker decision-making. A 79-year-old man with pre-existing first-degree AV block developed delayed CAVB 1 day after successful SP ablation for typical AVNRT. Transient PR interval shortening immediately post-ablation preceded progression to high-grade AV block. Subsequently, AV conduction gradually recovered without permanent pacemaker implantation, as confirmed using serial electrocardiography, treadmill exercise testing, and repeat electrophysiological studies. Electrophysiological evaluation showed impaired antegrade fast pathway (FP) conduction with complete absence of retrograde ventriculoatrial conduction, suggesting differential involvement of FP fibers. Delayed AV block after SP ablation may be reversible, particularly when preceded by PR interval shortening and when AV conduction improves under exercise or pharmacological stress. Careful functional assessment of AV conduction is needed before committing to permanent pacemaker implantation, as delayed AV block may reflect indirect and potentially reversible FP injury.

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Publication Details

Journal
Pacing and Clinical Electrophysiology
Published
2026-02-13
DOI
https://doi.org/10.1111/pace.70158
Primary Topic
Cardiac Arrhythmias and Treatments
Type
article
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article

Delayed CAVB After SP Ablation for AVNRT: Mechanistic Insights Into FP Injury and Pacing Decision‐Making

Seigo Masuda, N Honda, Taiki Kodama, Kiyohiro Ogawa et al.
Pacing and Clinical Electrophysiology
Cardiac Arrhythmias and Treatments
article

Delayed CAVB After SP Ablation for AVNRT: Mechanistic Insights Into FP Injury and Pacing Decision‐Making

Seigo Masuda, N Honda, Taiki Kodama, Kiyohiro Ogawa, Kotaro Tasaki, Mio Hino
article en

Abstract

As standard therapy for atrioventricular nodal re-entrant tachycardia (AVNRT), radiofrequency ablation of the antegrade slow pathway (SP) is associated with a low risk of AV block. Delayed complete AV block (CAVB), however, is a rare but clinically challenging complication, particularly concerning permanent pacemaker decision-making. A 79-year-old man with pre-existing first-degree AV block developed delayed CAVB 1 day after successful SP ablation for typical AVNRT. Transient PR interval shortening immediately post-ablation preceded progression to high-grade AV block. Subsequently, AV conduction gradually recovered without permanent pacemaker implantation, as confirmed using serial electrocardiography, treadmill exercise testing, and repeat electrophysiological studies. Electrophysiological evaluation showed impaired antegrade fast pathway (FP) conduction with complete absence of retrograde ventriculoatrial conduction, suggesting differential involvement of FP fibers. Delayed AV block after SP ablation may be reversible, particularly when preceded by PR interval shortening and when AV conduction improves under exercise or pharmacological stress. Careful functional assessment of AV conduction is needed before committing to permanent pacemaker implantation, as delayed AV block may reflect indirect and potentially reversible FP injury.

Pacing and Clinical Electrophysiology
Hamanomachi Hospital (JP)
Peace, Justice and strong institutions
Openalex Percentile: Top 59%
Cardiac Arrhythmias and Treatments
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Delayed CAVB After SP Ablation for AVNRT: Mechanistic Insights Into FP Injury and Pacing Decision‐Making — Seigo Masuda, N Honda, et al. · Pacing and Clinical Electrophysiology (2026) | TGRS Research Map | TGRS