The EZH2-NEAT1 epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer
The <i>EZH2-NEAT1</i> axis functions as a pro-death pathway in cuproptosis execution machinery rather than a protective response. Tumors with elevated <i>EZH2-NEAT1</i> expression may be particularly sensitive to copper-based therapies. This study establishes <i>EZH2-NEAT1</i> expression as a potential biomarker for patient selection in cuproptosis-based cancer treatment, though the concurrent effects on tumor migration highlight complex therapeutic considerations for combination treatment strategies.
Authors
- C. Wang
- Ruibing Li (ORCID: https://orcid.org/0000-0002-1311-1012)
- Chuanyuan Liu
- Xijie Chen
- Qiang Tao (ORCID: https://orcid.org/0000-0002-9234-2352)
- Yijia Lin
- Huanmiao Zhan
- Xinyou Wang
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Ganzhou People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.21037/jgo-2025-1-1058
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts Department of Agricultural Resources
- China International Medical Foundation