S1PR3 antagonism ameliorates endothelial dysfunction in septic acute kidney injury through the ROCK1–Drp1 signalling pathway
Endothelial S1PR3 is a key mediator of mitochondrial dysfunction and barrier disruption in S-AKI. Liposomal delivery of S1PR3 antagonists represents a promising therapeutic strategy for preserving endothelial integrity and attenuating septic renal injury.
Authors
- Feng Wang (ORCID: https://orcid.org/0000-0003-1089-3095)
- Hanbin Wang (ORCID: https://orcid.org/0000-0002-9607-8114)
- Xing Fang
- Jueyue Yan
- Zhipeng Xu
- Qinghui Fu
- Jue Zhang
- Gan Luo
Institutions
- Fudan University (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1016/j.molimm.2026.02.004
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00