Enhancement of gastrointestinal anastomosis healing via a small intestinal submucosa bio-patch: modulating IL-22 secretion by type 3 innate lymphoid cells and microbial structures
SIS bio-patch promotes anastomotic healing by enhancing IL-22<sup>+</sup>ILC3-mediated repair, rebalancing adaptive immunity, reshaping microbial communities, and upregulating pro-regenerative metabolic pathways. These findings support the use of SIS as an immunomodulatory biomaterial for gastrointestinal repair.
Authors
- Wei-Ran Chen
- Naiyang Zhan
- Yuan Zhou (ORCID: https://orcid.org/0000-0002-1972-8507)
- Yongqiang Zhan
- Jia-Wen Zhao
- Hao-Jie Zhong
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Shenzhen Second People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fbioe.2026.1752619
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00