Risk stratification by donor-derived cell-free DNA: a three-year single center study of kidney transplant outcomes from 257 patients
Elevated dd-cfDNA levels were associated with adverse alloimmune and functional outcomes, including rejection, DSA positivity, and reduced graft survival (p=0.0071). A logistic regression model identified eGFR decline in the >1.0% group to predict long-term graft failure and patient survival (p=0.04). These findings support the clinical value of dd-cfDNA as a biomarker of alloimmune risk in kidney transplant recipients.
Authors
- Shirley Chang (ORCID: https://orcid.org/0000-0002-3329-5314)
- Kanishka Mohib (ORCID: https://orcid.org/0000-0002-7332-5530)
- Jon R. Von Visger
- Richard J. Quigg (ORCID: https://orcid.org/0000-0002-8546-7528)
- Samer Kareem
- Kabir Jalal (ORCID: https://orcid.org/0000-0002-6131-0542)
- Olivia Sorci
- Rhys Mendel
- Cynthia Wan
- Lin Liu
- Eric Zou
- John E. Tomaszewski
- Xiaoyan Wu
- Ying Huang
Institutions
- Medical Care Development (US)
- Jacobs Institute (US)
- Children's Research Hospital (JP)
- Jacobs (United States) (US)
- North Carolina School of Science and Mathematics (US)
- University of Virginia (US)
- University of Rochester (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fimmu.2026.1737024
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Washington
- University at Buffalo