Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response

Our findings demonstrate a dynamically regulated circRNA landscape in OA. Specific DECs appear to orchestrate joint immunity by potentially enhancing antigen presentation and macrophage polarization, thereby facilitating T-cell activation. These results position circRNAs as unrecognized immunoregulators in OA, nominating them as candidate biomarkers or therapeutic targets for modulating the joint immune microenvironment.