Coexistence of a blaNDM-5-Harboring IncHI2 Plasmid and an IncF Multidrug-Resistance Plasmid in a Clinical Escherichia coli Strain from Urine Sample of a Patient with Lower Limb Fracture

In the carbapenem-resistant <i>E. coli</i> strain EC6622 isolated from the urine sample of a 70-year-old patient with a lower limb fracture, the carbapenemase gene <i>bla</i> _NDM-5 was carried by the IncHI2/IncHI2A plasmid (pEC6622-1), while a coexisting IncFIB_AP001918/IncFII hybrid multidrug-resistance plasmid (pEC6622-2) was also identified. These findings provide detailed genetic information that enhances our understanding of the resistance mechanisms and potential dissemination routes of <i>bla</i> _NDM-harboring <i>E. coli</i>.