Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex

Together, these results demonstrate that acute modulation of pyramidal cell-fast-spiking interneuron synapses via group I mGluRs is conserved between human and rodent neocortex, while pointing to species-specific underlying mechanisms. Moreover, mGluR-mediated modulation exhibits cell-type specificity in human cortical circuits. Collectively, these findings provide direct functional evidence for group I mGluR-dependent synaptic regulation in the human cortex and highlight important species- and cell-type-specific differences that should be considered when extrapolating rodent data to human cortical physiology and disease mechanisms.