NMR metabolomics reveals metabolic alterations in a novel mouse model of neurodegeneration
The <i>dcr</i> mice show evidence of significant metabolic dysregulation and add to the existing literature on the metabolic consequences of neurodegeneration. This work motivates future studies to understand the connection between mitochondrial dysfunction, metabolic alterations and neurodegeneration using the <i>dcr</i> mouse model.
Authors
- Nikita Harvey (ORCID: https://orcid.org/0000-0002-2533-6980)
- Haley Adams (ORCID: https://orcid.org/0009-0002-9542-5978)
- Grace V. Mercer
- Lindsay S. Cahill (ORCID: https://orcid.org/0000-0003-1667-8564)
- Sophie Kiefte
- Drew P. Locke
- Rachel Coffey
- Grace V. Mercer
Institutions
- Memorial University of Newfoundland (CA)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fnins.2026.1776973
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer Society
- Alzheimer Society Research Program