OnCorr: A pan-cancer mRNA-protein correlation tool for precision oncology
Proteins are ultimately responsible for cellular phenotypes and are targeted by most anticancer drugs. However, beyond immunohistochemistry, proteins are not typically measured in precision oncology, meaning transcriptomics is used as a proxy. To determine how informative mRNA is for guiding personalised treatments, mRNA-protein correlations were analysed in three large pan-cancer datasets and made available in a web portal ( https://oncorr.aws.procan.org.au/ ). OnCorr can be integrated into precision medicine programs to augment transcriptomics.
Authors
- Urwah Nawaz (ORCID: https://orcid.org/0000-0002-3703-4445)
- R Reddel
- Michael Lee (ORCID: https://orcid.org/0000-0001-7750-9145)
- Rebecca C. Poulos (ORCID: https://orcid.org/0000-0002-8419-7028)
- Chelsea Mayoh (ORCID: https://orcid.org/0000-0002-6398-3046)
- Bhavna Padhye (ORCID: https://orcid.org/0000-0003-0740-3606)
- Niantao Deng
- Ori Livson
Institutions
- The University of Sydney (AU)
- Children's Medical Research Institute (AU)
- Children's Hospital at Westmead (AU)
- UNSW Sydney (AU)
- Children's Cancer Institute Australia (AU)
- Sydney Children's Hospital (AU)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1038/s41698-026-01323-2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Medical Research
- David and Elaine Potter Foundation
- European Commission
- Australian Cancer Research Foundation
- National Breast Cancer Foundation
- Cancer Institute NSW
- NSW Ministry of Health
- Medical Research Council
- National Health and Medical Research Council
- Cancer Council NSW
- National Cancer Institute