A modular pipeline for natural language processing-screened human abstraction of a pragmatic trial outcome from electronic health records

We present the design and source code for a scalable and efficient pipeline for measuring complex electronic health record-derived outcomes using natural language processing-screened human abstraction. This implementation is adaptable to diverse research needs, and its modular pipeline represents a practical middle ground between custom software and commercial platforms.

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Publication Details

Journal
Clinical Trials
Published
2026-02-12
DOI
https://doi.org/10.1177/17407745251405386
Primary Topic
Machine Learning in Healthcare
Type
article
Field-Weighted Citation Impact
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article

A modular pipeline for natural language processing-screened human abstraction of a pragmatic trial outcome from electronic health records

Danae Dotolo, Trevor Cohen, Jessica Walsh, Kasey Mallon Andrews et al.
Clinical Trials
Machine Learning in Healthcare
article

A modular pipeline for natural language processing-screened human abstraction of a pragmatic trial outcome from electronic health records

Danae Dotolo, Trevor Cohen, Jessica Walsh, Kasey Mallon Andrews, Robert Y. Lee, Erin K. Kross, Elizabeth L. Nielsen, Nicole Leduc, WB Lober, James Sibley, Janaki O’Brien, Kevin S Li, Anna Ungar
article en

Abstract

We present the design and source code for a scalable and efficient pipeline for measuring complex electronic health record-derived outcomes using natural language processing-screened human abstraction. This implementation is adaptable to diverse research needs, and its modular pipeline represents a practical middle ground between custom software and commercial platforms.

Clinical Trials
New Mexico Department of Health (US), University of New Mexico (US), University of Washington (US), Cambia (AU), University of Washington Medical Center (US), Neurobehavioral Systems (US), Seattle Children's Hospital (US)
Quality Education
Openalex Percentile: Top 59%
Machine Learning in Healthcare
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A modular pipeline for natural language processing-screened human abstraction of a pragmatic trial outcome from electronic health records — Danae Dotolo, Trevor Cohen, et al. · Clinical Trials (2026) | TGRS Research Map | TGRS