Electroacupuncture and Moxibustion Regulate Aerobic Glycolysis and Alleviate Tumor Progression in Mice with Hepatocellular Carcinoma

The study reveals that both electroacupuncture and moxibustion alleviate tumor proliferation in HCC mice by suppressing the NSUN2-PKM2 glycolytic axis, thereby highlighting this pathway as a novel metabolic target for non-pharmacological intervention; moreover, moxibustion uniquely exhibits the potential to induce a more extensive metabolic stress response. The observed reductions in tumor burden and key biomarkers corroborate the therapeutic potential of this approach. Collectively, these preclinical findings suggest that electroacupuncture and moxibustion, as non-pharmacological adjunctive therapies, hold translational potential for modulating tumor metabolism and slowing HCC progression, warranting further clinical investigation.