Microbiome of Apical Intracanal and Extraradicular Biofilms From the Same Roots of Teeth With Persistent Apical Periodontitis: An Observational Study
While comparison of the microbiome between extraradicular and intracanal biofilms of the same root apices revealed differences in bacterial composition, certain similarities were noted, particularly in dominant bacterial species abundance, indicating a close microbial relationship between intracanal and extraradicular biofilms, with some exceptions. Additionally, some differences in predicted functional profiles were observed between the two biofilm types. Thus, the characterisation of bacterial communities around the apical foramen may guide the development of appropriate antimicrobial strategies.
Authors
- Daisuke Motooka (ORCID: https://orcid.org/0000-0002-4616-9608)
- Nanako Kuriki (ORCID: https://orcid.org/0000-0002-2931-3583)
- Yoko Asahi (ORCID: https://orcid.org/0000-0001-9443-5790)
- Tsuyoshi Shimaoka (ORCID: https://orcid.org/0009-0006-9625-1921)
- Mikako Hayashi (ORCID: https://orcid.org/0000-0002-3375-9027)
- Kittipit Klanliang (ORCID: https://orcid.org/0009-0004-0274-0851)
- Shigeyuki Ebisu
- Shota Nakamura (ORCID: https://orcid.org/0000-0002-1865-0867)
- Motoki Okamoto
- Hazuki Maezono
- Tetsuya Iida
- Yuichiro Noiri
Institutions
- Osaka Gakuin University (JP)
- Chiang Mai University (TH)
- Niigata University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1111/iej.70113
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00