WASHC3 knockout disrupts mitochondrial protein homeostasis and energy metabolism in cardiomyocytes
These findings identify a previously unrecognized role for WASHC3 in maintaining cardiac mitochondrial protein homeostasis and bioenergetic function and provide a framework linking neuromuscular and cardiac phenotypes to impaired mitochondrial bioenergetics in energy-demanding tissues.
Authors
- Deung-Dae Park (ORCID: https://orcid.org/0000-0001-6265-4964)
- S. Y. Kim (ORCID: https://orcid.org/0000-0002-1029-487X)
- Amelia A. Glazier (ORCID: https://orcid.org/0000-0002-3248-5773)
- Steffen Just (ORCID: https://orcid.org/0000-0001-7396-1281)
- W Rottbauer
Institutions
- Universität Ulm (DE)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fcvm.2026.1682381
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung