Whole-brain in situ postmortem MR imaging using a combination of sequences for cortical lesion detection in multiple sclerosis
Despite using advanced MRI sequences in a highly controlled postmortem setting, cortical lesion detection remains limited at 17.4%. The combination of DIR and PSIR sequences provides the most effective approach, significantly outperforming conventional sequences. These findings establish a reference benchmark for cortical lesion detection rates and highlight persistent limitations of current MRI technology for identifying cortical pathology in multiple sclerosis.
Authors
- Lukas Haider (ORCID: https://orcid.org/0000-0002-1556-1770)
- Piet M. Bouman (ORCID: https://orcid.org/0000-0003-2698-4004)
- Jeroen J. G. Geurts
- Laura E. Jonkman
- Menno M. Schoonheim
- Frederik Barkhof
Institutions
- Queen Mary University of London (GB)
- Amsterdam Neuroscience (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Medical University of Vienna (AT)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- La radiologia medica
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1007/s11547-026-02185-1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00