Engineering Industrial Strain of Acremonium chrysogenum for Deacetoxycephalosporin C Overproduction Using CRISPR/Cas9
This demonstrates that CRISPR/Cas9 can effectively edit industrial <i>A. chrysogenum</i>, providing a strategy to enhance the production of other cephalosporin precursors.
Authors
- Yifan Sun (ORCID: https://orcid.org/0000-0002-4082-5379)
- Xiaozhi Ju
- Shu‐Shan Gao (ORCID: https://orcid.org/0000-0001-6335-2052)
- Q. P. Hu (ORCID: https://orcid.org/0000-0002-5781-8853)
- Mengliu Peng
- Liping Du
- Ye Liang
Institutions
- Tianjin University of Science and Technology (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Antibiotics
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3390/antibiotics15020202
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences