Investigating the relationship between osteoporosis and rheumatoid arthritis: prospective cohort study and genetic analyses
Our work demonstrates a significant biological pleiotropy as well as a putative causal relationship between OP and RA, emphasizing an intrinsic link underlying the pronounced phenotypic association. These findings highlight the possibility of preventing and predicting RA development by monitoring and interfering with bone loss in preclinical high-risk individuals.
Authors
- Qiurong He
- Jian Xu (ORCID: https://orcid.org/0000-0003-4886-4708)
- Yunjie Liu (ORCID: https://orcid.org/0000-0001-9454-5666)
- Li Sun (ORCID: https://orcid.org/0000-0002-2454-741X)
- Xuan Wu (ORCID: https://orcid.org/0000-0001-8539-6611)
- Xiaofeng Ma (ORCID: https://orcid.org/0000-0003-3725-1391)
- Yiping Jia
- Xia Jiang (ORCID: https://orcid.org/0000-0002-8597-8520)
- Yanqiu Zou
- Min Tang (ORCID: https://orcid.org/0000-0002-0716-912X)
- Li Ji
- Di Zhang (ORCID: https://orcid.org/0000-0001-6565-0088)
- Ben Li Zhang
- Wenzhi WANG
- B W Lei
- Lingli Qiu
- Zhixin Tan
- Xiaoling Wen
- Lin Chen
- Mengyu Fan
- Yutong Wang
- Lu Wang
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- Karolinska Institutet (SE)
- West China Hospital of Sichuan University (CN)
- Hainan General Hospital (CN)
- Nanchang Center for Disease Control and Prevention (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Therapeutic Advances in Musculoskeletal Disease
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1177/1759720x251412846
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00