Multimodal phenotyping of ARDS: design and preliminary insights from the prospective BIOWARE cohort for precision critical management
The BIOWARE cohort provides a multidimensional framework that captures dynamic interactions among physiology, pulmonary structural changes, and host response, enabling identification of ARDS endotypes grounded in biological mechanisms. This integrative strategy represents a paradigm shift from syndrome-based classification toward mechanism-driven precision care, establishing a transformative platform for targeted therapeutic development.
Authors
- Xian Huang (ORCID: https://orcid.org/0000-0002-8788-9185)
- Xiangyou Yu (ORCID: https://orcid.org/0000-0003-2252-0472)
- Chaofu Yue (ORCID: https://orcid.org/0000-0002-7610-9526)
- Qianlin Wang (ORCID: https://orcid.org/0000-0003-4942-3197)
- Shulin Zhang (ORCID: https://orcid.org/0000-0003-2007-6814)
- Yingying Yang (ORCID: https://orcid.org/0000-0001-6779-080X)
- Keyi Zhao (ORCID: https://orcid.org/0000-0001-6361-5588)
- Chunbo Yang
- Song Zhang
- Yongjie Wang
- Xin Yu
- Siqing Ma
- Fang Wang
- Zuxi Niu
- Zhiqiang Zhu
- Mei Yang
- Yun Long
- Qiang Sun
- Longxiang Su
- Min Yang
- Weida Liu
- Ziqi Tan
Institutions
- Xinjiang Medical University (CN)
- Anhui Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- People 's Hospital of Jilin Province (CN)
- Qujing Normal University (CN)
- Heze Municipal Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Qinghai Provincial Peoples Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Affiliated Hospital of Jining Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1186/s12931-026-03571-z
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00