Hamartoma of the Nasal Vestibule: Case Report and Review of Literature

Respiratory epithelial adenomatoid hamartoma (REAH) represents a category of tumor-like lesion arising from congenital developmental anomalies, characterized by aberrant differentiation or maturational arrest of multiple tissue lineages during embryogenesis. The predominant anatomical site involves the nasal cavity, specifically the nasal septum, with additional potential locations including the middle meatus and ethmoidal sinuses. Definitive diagnosis generally requires histopathological examination. These uncommon nasal neoplasms are amenable to complete excision through endoscopic surgical approaches performed under general anesthesia. A 55-year-old patient with nasal vestibular REAH presented with nasal obstruction, intermittent nasal pruritus, and diminished olfactory function. Clinical examination detected an ovoid mass in the right nasal vestibule, while radiological imaging demonstrated soft tissue density in the corresponding area. The diagnosis of REAH was confirmed through histopathological assessment after complete surgical excision. The patient fortunately experienced no procedure-related complications throughout the perioperative course and follow-up period. Postoperative surveillance through scheduled follow-up examinations is essential to prevent local recurrence.

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Journal
Ear Nose & Throat Journal
Published
2026-02-12
DOI
https://doi.org/10.1177/01455613261420071
Primary Topic
Head and Neck Surgical Oncology
Type
article
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article

Hamartoma of the Nasal Vestibule: Case Report and Review of Literature

Xin Pan, Xin Wei, YaNan Li
Ear Nose & Throat Journal
Head and Neck Surgical Oncology
article

Hamartoma of the Nasal Vestibule: Case Report and Review of Literature

Xin Pan, Xin Wei, YaNan Li
article en

Abstract

Respiratory epithelial adenomatoid hamartoma (REAH) represents a category of tumor-like lesion arising from congenital developmental anomalies, characterized by aberrant differentiation or maturational arrest of multiple tissue lineages during embryogenesis. The predominant anatomical site involves the nasal cavity, specifically the nasal septum, with additional potential locations including the middle meatus and ethmoidal sinuses. Definitive diagnosis generally requires histopathological examination. These uncommon nasal neoplasms are amenable to complete excision through endoscopic surgical approaches performed under general anesthesia. A 55-year-old patient with nasal vestibular REAH presented with nasal obstruction, intermittent nasal pruritus, and diminished olfactory function. Clinical examination detected an ovoid mass in the right nasal vestibule, while radiological imaging demonstrated soft tissue density in the corresponding area. The diagnosis of REAH was confirmed through histopathological assessment after complete surgical excision. The patient fortunately experienced no procedure-related complications throughout the perioperative course and follow-up period. Postoperative surveillance through scheduled follow-up examinations is essential to prevent local recurrence.

Ear Nose & Throat Journal
Gansu Provincial Hospital (CN), First Hospital of Lanzhou University (CN), Lanzhou University (CN)
Good health and well-being
Openalex Percentile: Top 58%
Head and Neck Surgical Oncology
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Hamartoma of the Nasal Vestibule: Case Report and Review of Literature — Xin Pan, Xin Wei, et al. · Ear Nose & Throat Journal (2026) | TGRS Research Map | TGRS