Integrative Multimodal Subtyping, Risk of Incident Mild Cognitive Impairment, and Differential Cardiometabolic Treatment Effects: A Prospective Cohort Study in the All of Us Research Program
Integrative subtyping based on comorbid, behavioral, and social risk factors reveals clinically meaningful heterogeneity in both cognitive risk and treatment response. Aligning dementia prevention strategies with dominant vulnerability pathways may enhance the effectiveness and equity of population-level precision prevention.
Authors
- Yinjun Zhao (ORCID: https://orcid.org/0000-0002-0111-3694)
- K. Marder (ORCID: https://orcid.org/0000-0003-0117-1429)
- Yuanjia Wang
Institutions
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-11
- DOI
- https://doi.org/10.64898/2026.02.10.26345240
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Mental Health