4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from <i>Chaetomium brasiliense</i>
A new depsidone, termed mollicellin Z2 (1), and three known mollicellins D, H, and I (2-4), were isolated from cultured Chaetomium brasiliense NBRC 6548 mycelia. The structure of 1 was determined from one dimensional (1D) and 2D-NMR and high resolution electron ionization (HREI)MS spectra. It is the first 4-desmethyl mollicellin analogue found to contain a C-7 prenyl group and is likely generated via a biosynthetic pathway that is distinct from those that produce the 27 known analogues. This is the first report of mollicellin derivatives with antibacterial activity against nontuberculous mycobacteria.
Authors
- Aki Hirabayashi (ORCID: https://orcid.org/0000-0003-3115-0645)
- Sho Furumura
- Teigo ASAI
- Taro Ozaki (ORCID: https://orcid.org/0000-0002-4673-4478)
- Y. Oshima
- Yoshihiko Hoshino (ORCID: https://orcid.org/0000-0002-3132-0715)
- Yohei Morishita (ORCID: https://orcid.org/0000-0001-8442-8642)
- Hanako Fukano (ORCID: https://orcid.org/0000-0003-2143-1160)
- Masato Suzuki
- Shuntaro Morita
Institutions
- Tohoku University (JP)
- National Institute of Infectious Diseases (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1248/cpb.c25-00729
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Advanced Low Carbon Technology Research and Development Program