CD14-deficiency protects against osteoarthritic subchondral bone sclerosis via enhanced osteoclastogenesis following joint injury

Osteoarthritis is one of the leading causes of disability worldwide. One of the hallmarks is subchondral sclerosis, or thickening of the bone in and around the joint. In this work, we used a mouse model of osteoarthritis to show that decreasing inflammatory signaling, through removal of CD14, protects against subchondral sclerosis, due to an increased presence of osteoclasts, cells that combat bone thickening. Osteoclasts without CD14 differentiate faster than osteoclasts with CD14, due to decreased Type I Interferon, an inflammatory cytokine.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-02-11
DOI
https://doi.org/10.64898/2026.02.10.705094
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
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article

CD14-deficiency protects against osteoarthritic subchondral bone sclerosis via enhanced osteoclastogenesis following joint injury

Christine B. Chung, Jonathan J. Miner, Kevin G. Burt, Vu Nguyen et al.
bioRxiv (Cold Spring Harbor Laboratory)
Osteoarthritis Treatment and Mechanisms
article

CD14-deficiency protects against osteoarthritic subchondral bone sclerosis via enhanced osteoclastogenesis following joint injury

Christine B. Chung, Jonathan J. Miner, Kevin G. Burt, Vu Nguyen, Baofeng Hu, Áurea Rodrigues Borges, Carla R. Scanzello, Kate Sharp, Robert L Mauck, Lance A Murphy
article en

Abstract

Osteoarthritis is one of the leading causes of disability worldwide. One of the hallmarks is subchondral sclerosis, or thickening of the bone in and around the joint. In this work, we used a mouse model of osteoarthritis to show that decreasing inflammatory signaling, through removal of CD14, protects against subchondral sclerosis, due to an increased presence of osteoclasts, cells that combat bone thickening. Osteoclasts without CD14 differentiate faster than osteoclasts with CD14, due to decreased Type I Interferon, an inflammatory cytokine.

bioRxiv (Cold Spring Harbor Laboratory)
San Francisco VA Medical Center (US), Hospital of the University of Pennsylvania (US), University of California San Diego (US), Philadelphia VA Medical Center (US), University of Pennsylvania (US), Philadelphia University (US)
Good health and well-being
Openalex Percentile: Top 59%
Osteoarthritis Treatment and Mechanisms
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CD14-deficiency protects against osteoarthritic subchondral bone sclerosis via enhanced osteoclastogenesis following joint injury — Christine B. Chung, Jonathan J. Miner, et al. · bioRxiv (Cold Spring Harbor Laboratory) (2026) | TGRS Research Map | TGRS